Supaart Sirikantaramas, Associate Professor, Ph.D.

Supaart Sirikantaramas, Associate Professor, Ph.D.

B.Sc., Chulalongkorn University
M.Sc. Kyushu University, Japan
Ph.D., Kyushu University, Japan

Office: Room 515/3, Science 10 Building 
Phone: 662-218-5425
Fax:      662-218-5418 
Email: Supaart.S@chula.ac.th

Research

  1. Molecular cloning and characterization of rice antimicrobial peptides
  2. Metabolomics of stress-tolerant rice
  3. Enhancing phytonutrients in cruciferous vegetables
  4. Starch biosynthesis in cassava
  5. Engineering cyanobacteria for the production of plant bioactive compounds

Professional experiences

May, 1997 – March, 1998 Researcher (Cosmetic products) “Development of liposome-based cosmetic products” Research and Development Division, Biophile Corporation, Thailand

May, 2005 – February, 2008 Post-doctoral researcher, Laboratory of Molecular Biology and Biotechnology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan

April, 2008 – September, 2010 Post-doctoral researcher, Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Copenhagen, Denmark

Recent Publications

Publications

  • Boonrueng, C.; Tangpranomkorn, S.; Yazhisai, U.; Sirikantaramas, S.. Molecular cloning, subcellular localization and characterization of two adenylate kinases from cassava, Manihot esculenta Crantz cv. KU50. Journal of Plant Physiology 2016, 204, 66-73.
  • S. Tantong, O. Pringsulaka, K. Weerawanich, A. Meeprasert, T. Rungrotmongkol, R. Sarnthima, S. Roytrakul, S. Sirikantaramas. Two novel antimicrobial defensins from rice identified by genecoexpression network analyses, Peptides, 2016; 84, 7–16.
  • Tantong, S.; Incharoensakdi, A.; Sirikantaramas, S.; Lindblad, P.. Potential of Synechocystis PCC 6803 as a novel cyanobacterial chassis for heterologous expression of enzymes in the trans-resveratrol biosynthetic pahtway. Protein Expression and Purification 2016, 121, 163-168.
  • Sirikantaramas, S.; Meeprasert, A.; Rungrotmongkol, T.; Fuji, H.; Hoshino, T.; Sudo, H.; Yamazaki, M.; Saito, K..Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations. Phytochemistry 2015, 113(17), 50-56.
  • Sirikantaramas, S.; Yamazaki, M.; Saito, K. Camptothecin: Biosynthesis, biotechnological production and resistance mechanism(s). Advances in Botanical Research 2013, 68, 139-161.
  • Yamazaki, M., Asano, T., Yamazaki, Y.,Sirikantaramas, S., Sudo, H., Saito, K. (2010) Biosynthetic system of camptothecin: An anticancer plant product. Pure Appl. Chem. 82, 213-218.
  • Sirikantaramas, S., Yamazaki, Y., Saito, K.(2009) A survival strategy: the coevolution of the camptothecin biosynthetic pathway and self-resistance mechanism. Phytochemistry 70, 1894-1898.
  • Lehmann, M., Schwarzländer, M., Obata, T., Sirikantaramas, S., Burow, M., Olsen, C.E., Tohge, T., Fricker, M.D., Møller, B.L., Fernie, A.R., Sweetlove, L.J., and Laxa, M. (2009) The metabolic response of Arabidopsis roots to oxidative stress is distinct from that of heterotrophic cells in culture and highlights a complex relationship between the levels of transcripts, metabolites, and flux. Mol. Plant. 2,
    390-406.
  • Sirikantaramas, S., Yamazaki, M., and Saito, K. (2008) Mechanisms of resistance to self-produced toxic secondary metabolites in plants. Phytochem. Rev.7, 467-477.
  • Sirikantaramas, S., Yamazaki, M., and Saito, K. (2008) Mutation in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants. Proc. Natl.Acad. Sci. USA.105(18), 6782-6786.
  • Sirikantaramas, S., Asano, T., Sudo, H., Yamazaki, M., and Saito, K. (2007) Transport of camptothecin in hairy roots of Ophiorrhiza pumila. Phytochemistry 68 (22-24), 2881-2886.
  • Taura, F., Dono, E., Sirikantaramas, S., Yoshimura, K., Shoyama, Y., and Morimoto, S. (2007) Production of tetrahydrocannabinolic acid by the biosynthetic enzyme secreted from transgenic Pichia pastoris. Biochem. Biophys. Res. Commun. 361(3), 675-680.
  • Taura, F., Sirikantaramas, S., Shoyama, Y., Yoshikai, K., Shoyama, Y., and Morimoto, S. (2007) Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa. FEBS Lett. 581(16), 2929-2934. 9.
  •  Sirikantaramas, S., Taura, F., Morimoto, S., and Shoyama, Y. (2007) Recent advances in Cannabis sativa research: biosynthetic studies and potential in biotechnology. Curr. Pharm. Biotech. 8(4), 237-243.
  • Sirikantaramas, S., Asano, T., Sudo, H, Yamazaki, M., and Saito, K. (2007) Camptothecin: Therapeutic potential and biotechnology. Curr. Pharm. Biotech. 8(4), 196-202.
  • Sirikantaramas, S., Taura, F., Tanaka, Y., Ishikawa, Y., Morimoto, S., and Shoyama, Y. (2005). Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of glandular trichome. Plant Cell Physiol. 46(9), 1578-1582.
  • Sirikantaramas, S., Morimoto, S., Shoyama, Y., Ishikawa, Y., Wada, Y., Shoyama, Y., and Taura, F. (2004). The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Δ1-tetrahydrocannabinolic acid synthase from Cannabis sativa L. J. Biol. Chem. 279 (38), 39767-39774.