Thailand has earned her reputation as one of the top ten food producing nations globally, with several agricultural products of high economic importance such as rice, cassava, and shrimp. Research conducted at the Department of Biochemistry is directed towards the sustainability of competitiveness of our agricultural products. This has been achieved using biotechnology coupled with multi-omics approach to improve the quality as well as to enhance the production efficiency and to make value-added products. The department is also actively engaged in bioenergy research with particular emphasis on biofuels such as biodiesel and biohydrogen. Achievements in this line of research can help alleviate the problem of global warming as well as support the use of alternative energy resources for the energy supply in Thailand in the near future. Research topics performing at the Department of Biochemistry at Chulalongkorn University provide broad, interdisciplinary and collaborative research.