Rath Pichyangkura, Assistant Professor, Ph.D.

Assistant Prof. Rath Pichyangkura, Ph.D.

B.Sc., Chulalongkorn University 
Ph.D., Michigan State University

Office: Room 725, Science 10 Building 
Phone: 662-218-5437
Fax: 662-218-5418 
Email: prath@chula.ac.th

1988-1996            Ph.D. in Biochemistry, Department of Biochemistry, Michigan State University, East Lansing, Michigan, USA
1984-1988            B.Sc. (Hons) in Biochemistry, Department of Biochemistry, Faculty of Science,  Chulalongkorn University, Bangkok, Thailand

Honors and Awards
2009-2010            Innovation Ambassador (Bio-Business), National Innovation Agency, THAILAND
2006-2008            Innovation Ambassador (Bio-Business), National Innovation Agency, THAILAND
1996-1998            Anandhamahidol Scholarship for MS. and Ph.D. degree, Anandhamahidol Foundation, Thailand
1988                     Distinguish Academic Awards, Taab Nelaniti Foundation, Thailand

Administrative Positions
2008-2011            Deputy Dean, Science and Technology Service Affairs, Faculty of Science, Chulalongkorn    University
2005-2008            Center Head, Center for Chitin-Chitosan Biomaterials, Metallurgy and Materials Science Research Institute, Chulalongkorn University

Research Experiences
2006                      Research Fellow, JSPS-NRCT, Osaka City University, Osaka, Japan
2003                      Research Fellow, University of Monpellier, France
2001                      ITIT Fellow, Osaka National Research Institute, Agency of Industrial and Technology,
                              Ministry of International trade and Industry, Japan  (Feb-Mar, 2001)
2000                      AIST Fellow, Osaka National Research Institute, Agency of Industrial and Technology, Ministry of International trade and Industry, Japan (Feb-Mar, 2000)

1996-present        Member of the Science Society of Thailand
1997-1998           Member of the Institutional Animal Care and Use Committee, National Laboratory Animal Centre, Mahidol University, Thailand

Industrial Linkage
2016                      Project Advisor and Project Leader (Talent Mobility), Thai Union Global Innovation Incubator  (TU GII)  
2015                      Project Advisor for Mitr Phol Sugar Group   
2015                      Training on chitin-chitosan and its application in food production for Betagro Group   
2009                      Founded Spin-off company, “Olizac Tecnologies Company Limited   ” through Chulalongkorn University Business Incubator    

Grants and Funding
2017-2018            National Research Council of Thailand: “Enzymatic transformation of sucrose for the production  of polysaccharides and oligosaccharides of glucose and fructose for food and functional food  applications”
2013-2015            National Research Council of Thailand:  “Development of  oligosaccharides  from agricultural product and waste from food industry as functional food and nutraceutical product”
2013-2014            Agricultural Research Development Agency (ARDA) 
2012-2014            Rachdaphiseksomphot Endownment Fund Part of the “Strengthen CU’s Researcher’s Project”
2010-2011            YRC textile company limited
2008-2009            Betagro Company, Thailand 
2006-2008            Agricultural Research Development Agency (ARDA)
2005-2006            Effem Foods company, Thailand
2003-2005            National Metal and Material Technology Center (MTEC) Research Grant
2003-2005            Rachadapiseksompoj Endowment 
2001-2002            TISTR Research Grant
2000-2004            National Center for Genetic Engineering and Biotechnology Research Grant
1998-1999            Rachadapiseksompoj Endowment fund
1997-1998            Post-doctoral grant, Thailand Research Fund, Thailand
1997-1999            Graduate Consortium in Computational Science and Engineering Program Grant,  National Science and Technology Development Agency, Thailand

2010                     WO/2010/012039 PROCESS FOR RECOVERING PROTEINS FROM CRUSTACEAN                              EXOSKELETONS. Kudan S., Trakunnaluamsai S., Kuttiyawong K., Pichyangkura R., Sangmanee                              S., Srikiatden J., Srirangsit T., Bates D., and Surawski J.


Recent Publications


2017                      Suthongsa, S.; Pichyangkura, R.; Kalandakanond-Thongsong, S.; Thongsong, B..  Effects of dietary levels of chito-oligosaccharide on ileal digestibility of nutrients, small intestinal  morphology and crypt cell proliferation in weaned pigs. Livestock Science 2017, 198, 37-44.

2016                      Muangsawang N., Pichyangkura R.*, Chandrachai A., Charoenrath O. (20XX)
                              Researchers’ viewpoints towards commercialization of agricultural technology for community   development. Int. J. Economic Policy in Emerging Economies, Vol. X, No. Y, xxxx ——-In Press 

2016                      Kunanusornchai W., Witoonpanich B., Pichyangkura R.,  Chatsudthipong  V., and   Muanprasat  C. (2016) Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: an in vitro and in vivo study. Pharmacol Res 113 : 458-467 http://dx.doi.org/doi:10.1016/j.phrs.2016.09.016

2016                      Kanjanatanin P., Pichyangkura R., and Chunsrivirot S.. (2016) Replica exchange molecular dynamics simulations reveal the structural and molecular properties of levan-type fructooligosaccharides of various chain lengths. BMC Bioinformatics 17:306, DOI  10.1186/s12859-016-1182-7

2016                      Mattaveewong T., Wongkrasant P., Chanchai S., Pichyangkura R., Chatsudthipong V., Muanprasat C. (2016) Chitosan oligosaccharide suppresses tumor progression in a mouse model of colitis-associated colorectal cancer through AMPK activation and suppression of NFkB and mTOR signaling. Carbohydrate Polymers 145; 30–36, http://dx.doi.org/10.1016/j.carbpol.2016.02.077

2016                      Sangmanee S., Nakapong S., Pichyangkura R. and Kuttiyawong K. (2016) Levan Type Fructooligosaccharide production using Bacillus licheniformis RN-01 levansucrase Y246S immobilized on chitosan beads. Songklanakarin J. Sci. Technol.
                              38 (3), 295-303

2016                      Kananont, N., Pichyangkura, R., Kositsup, B., Wiriyakitnateekul, W., Chadchawan, S. (2016) Improving the rice performance by fermented chitin waste. International Journal of Agriculture and Biology 18(1): 9-15, DOI: 10.17957/IJAB/15.0045D

2015                      Supachaturat S., Pichyangkura R., Chandrachai A., and Pentrakoon D.(2015) A Turning Point to Successful Entrepreneurship in Case Thai Functional Food Company.  International  Journal of Social Science and Humanity, 5 (9): 804-807

2015                      Pichyangkura R. and Chadchawan S. (2015) Biostimulant activity of chitosan in horticulture. Scientia Horticulturae 196: 49–65,  DOI: 10.1016/j.scienta.2015.09.031

2015                      Muymas P., Pichyangkura R., Wiriyakitnateekul W., Wangsomboondee T., Chadchawan S. and Seraypheap K. (2015) Effects of chitin-rich residues on growth and postharvest quality of lettuce. Biological Agriculture & Horticulture: An International Journal for Sustainable  Production Systems, 31:2, 108-117, DOI: 10.1080/01448765.2014.974669

2015                     Muanprasat C, Wongkrasant P, Satitsri S, Moonwiriyakit A, Pongkorpsakol P, Mattaveewong T,  Pichyangkura R, and  Chatsudthipong V. (2015) Activation of AMPK by chitosan  oligosaccharide in intestinal epithelial cells: mechanism of action and potential applications  in  intestinal disorders. Biochem Pharmacol. 96: 225-236   DOI: 10.1016/j.bcp.2015.05.016

2015                      Sangmanee S., Nakapong S., Kuttiyawong K. and Pichyangkura R. (2015) Production and  Immobilization of Levansucrase. Chiang Mai J. Sci; 42(1): 44-51

2015                      Chamnanmanoontham N., Pongprayoon W., Pichayangkura R., Roytrakul S., and•  Chadchawan S. (2015) Chitosan enhances rice seedling growth via gene expression network between nucleus and chloroplast. Plant Growth Regul 75:101–114, DOI 0.1007/s10725-014-9935-7

2014                      Srisornkompon P., Pichyangkura R., and Chadchawan S. (2014) Chitosan Increased Phenolic Compound Contents in Tea (Camellia sinensis) Leaves by Pre- and Post-Treatments. J. Chitin Chitosan Sci. 2(2):  93-98

2014                      Kananont N., Kositsup B., Pichyangkura R., and Chadchawan S. (2014) Effects of Chitosan  and Associated Solvents on the Growth of ‘Pathumthani1’ Rice (Oryzasativa L. ‘Pathumthani1’)  Seedlings. J. Chitin Chitosan Sci. 2: 99-105

2014                      Chantarasataporn P, Tepkasikul P, Kingcha Y, Yoksan R, Pichyangkura R, Visessanguan W,   Chirachanchai S. (2014) Water-based oligochitosan and nanowhisker chitosan as potential  food preservatives for shelf-life extension of minced pork. Food Chem. 159:463-70.  DOI: 10.1016/j

2014                      Khwanchai, P., Chinprahast, N., Pichyangkura, R., Chaiwanichsiri, S. (2014)                               Gamma-aminobutyric acid and glutamic acid contents, and the GAD activity in germinated brown rice (Oryza sativa L.): Effect of rice cultivars. Food Science and Biotechnology 23(2):   373-379

2013                      Pongprayoon W., Roytrakul S., Pichayangkura R., Chadchawan S. (2013) The role of hydrogen peroxide in chitosan-induced resistance to osmotic stress in rice (Oryza sativa L.) Plant Growth Regul DOI 10.1007/s10725-013-9789-4

2013                      Nakapong S., Pichyangkura R., Ito K, Iizuka M., Pongsawasdi P. (2013) High expression level of levansucrase from Bacillus licheniformis RN-01 and synthesis of levan nanoparticles. Int J Biol Macromol. 54:30-36

2012                      Keerati-Angkoon K., Pichyangkura R. and  Chandrachai A. (2012) Academic scientist’s motivation in research commercialization. Journal of Economics and Sustainable Development  3(9): 11-20

2012                      Wongputtaraksa T., Ratanavaraporn J., Pichyangkura R., Damrongsakkul S. (2012) Surface modification of Thai silk fibroin scaffolds with gelatin and chitooligosaccharide for enhanced osteogenic differentiation of bone marrow-derived mesenchymal stem cells. J Biomed Mater Res B Appl Biomater. 100(8):2307-15

2012                      Yousef M., Pichyangkura R., Soodvilai S., Chatsudthipong V., Muanprasat C. (2012) Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanism of action . Pharmacol Res 66: 66– 79

2012                      Muanprasat C., Yousef M., Pichyangkura R., Chatsudthipong V. (2012) Chitosan oligosaccharides ameliorate inflammation in two experimental models of colitis through inhibition of intestinal epithelial cell NF-kB signaling and apoptosis. FASEB Jorunal 26: 1107.5

2011                      Keerati-Angkoon K., Pichyangkura R.,Chandrachai A. (2011)   Information Management, Innovation Management and Industrial Engineering (ICIII)2011 International Conference on (Volume:2 ) 508-513

2011                      Kudan S., Kuttiyawong K., Pichyangkura R.  (2011) Carboxy-terminus truncations of Bacillus licheniformis SK-1 CHI72 with distinct substrate specificity. BMB reports, 44 (6): 375-380  

2011                      Nimpiboon P., Nakapong S., Pichyangkura R., Ito K., Pongsawasdi P. (2011) Synthesis of a novel prebiotic trisaccharide by a type i α-glucosidase from B. licheniformis strain TH4-2.  Process Biochemistry46 (2): 448-457  

2010                      Buaban B, Inoue H, Yano S, Tanapongpipat S, Ruanglek V, Champreda V, Pichyangkura R,  Rengpipat S, Eurwilaichitr L. (2010) Bioethanol production from ball milled bagasse using an on-site produced fungal enzyme cocktail and xylose-fermenting Pichia stipitis. J Biosci Bioeng. 110(1):18-25

2010                      Pornpienpakdee P., Singhasurasak R., Chaiyasap P., Pichyangkura R., Bunjongrat R., Chadchawan S., and Limpanavech P. (2010) Improving the micropropagation efficiency of hybrid Dendrobium orchids with Chitosan. Scientia Horticulturae, 124(4): 490-499

2010                      Kananont N., Pichyangkura R., Chanprame S., and Chadchawan S. (2010) Chitosan specificity for the in vitro seed germination of two Dendrobium orchids (Asparagales: Orchidaceae) Scientia Horticulturae, 124(2): 239-247

2010                      Kannasut P., Pichyangkura R., and Ratanamahatana C.A., (2010) Automatic 2-D Hydrophobic Cluster Alignment. International Journal of Biomedical Engineering and Technology, 3(1-2): 43-63

2009                      Vachiraroj N, Ratanavaraporn J, Damrongsakkul S, Pichyangkura R, Banaprasert T, Kanokpanont S. (2009)  A comparison of Thai silk fibroin-based and chitosan-based materials on in vitro biocompatibility for bone substitutes. Int J Biol Macromol. 45(5):470-477.

2009                      Kudan S. and Pichyangkura R. (2009) Purification and characterization of thermostable chitinase from Bacillus licheniformis SK-1. Appl Biochem Biotechnol. Apr; 157(1):23-35.

2009                      Suphasiriroj W, Yotnuengnit P, Surarit R, Pichyangkura R. (2009) The fundamental parameters of chitosan in polymer scaffolds affecting osteoblasts (MC3T3-E1). J. Mater Sci Mater Med. 2009 Jan; 20(1):309-20

2008                      Kuttiyawong K., Nakapong1 S., and Pichyangkura R. (2008) The dual exo/endo-type mode and the effect of ionic strength on the mode of catalysis of chitinase 60 (CHI60) from Serratia sp. TU09 and its mutants. Carbohydr. Res. November, 343(16), 2754-2762

2008                      Limpanavech P., Chaiyasuta S., Vongpromek R., Pichyangkura R., Khunwasi C., Chadchawan S., Lotrakul P., Bunjongrat R., Chaidee A., and Bangyeekhun T. (2008) Chitosan effects on floral production, gene expression, and anatomical changes in the Dendrobium orchid. Scientia Horticulturae 116: 65–72

2008                      Kachanechai T., Jantawat P. and Pichyangkura R. (2008) The influence of chitosan on physico-chemical properties of chicken salt-soluble protein gel.Food Hydrocolloids, 22: 74-83

2007                      Tangsadthakun C., Kanokpanont S., Sanchavanakit N., Pichyangkura R., Banaprasert T.,   Tabata Y. and Damrongsakkul S.(2007) The influence of molecular weight of chitosan on the physical and biological properties of collagen/chitosan scaffolds. J. Biomater. Sci. Polymer Edn,   18, No. 2, pp. 147–163

2006                      Tassanakajon A., Klinbunga S., Paunglarp N., Rimphanitchayakit V., Udomkit A., Jitrapakdee S., Sritunyalucksana K., Phongdara A., Pongsomboon S., Supungul P., Tang S, Kuphanumart K.,  Pichyangkura R., Lursinsap C. (2006) Penaeus monodon gene discovery project: the generation of an EST collection and establishment of a database. Gene. 384:104-112

2004                      Supungul P., Klinbunga S., Pichyangkura R., Hirono I., Aoki T., Tassanakajon A. (2004 ).  Antimicrobial peptides discovered in the black tiger shrimp Penaeus monodon using the EST approach. Dis Aquat Organ. 61(1-2):123-135.

2003                       Sashiwa H., Fujishima S., Yamano N., Kawasaki N., Nakayama A., Muraki E., Sukwattanasinitt M., Pichyangkura R., Aiba S. (2003) Enzymatic production of N-acetyl-D-glucossamine from chitin:Degradation study of N-acetylchitooligosaccharide and the effect of mixing of crude enzyme. Carbohydrate Polymers 51: 391-395

2002                  Pichyangkura R., Kudan S., Kuttiyawong K., Sukwattanasinitt M., and Aiba S. (2002).  Quantitative production of 2-Acetamido-2-deoxy-D-glucose from crystalline chitin by bacterial chitinase. Carbohydr. Res. 337, 557-559                

2002                      Supangul, P., Klinbungna, S., Pichyangkura, R., Jitrapakdee, Hirono, I., Aoki, T. and Tassanakajon, A. (2002). Identification of immune-related genes in haemocytes of the black tiger shrimp Penaeus monodon, Marine Biotechnology 4, 487-494

2001                      Supangul, P., Klinbungna, S., Pichyangkura, R., Hirono, I., Aoki, T. and Tassanakajon, A. Immune-related genes in haemocytes of the black tiger shrimp, Penaeus monodon, infected  with Vibrio harveyi, Fisheries Science 68:1083-1086

2000                      Mekkriengkrai D., Chirachanchai S., and  Pichyangkura R. (2000). Enzymatic degradation of   chitosan using Staphylococcus species strain TU005(E) chitinase. Journal of Metals, Materials and Minerals. 10 (1), 23-26

1999                      TalSinger R., Pichyangkura R., Chung E., Lasner T.M., Randazzo B.P., Trojanowski J.Q., Fraser N.W., and Triezenberg S.J. (1999). The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous system. Virology 259, 20-33

1995                      Moriuchi H., Moriuchi M., Pichyangkura R., Triezenberg S.J., Straus T.E., and Cohen J.I.  (1995). Hydrophobic cluster analysis predicts an amino-terminal domain of varicella-zoster virus open reading frame 10 required for transcription activation. Proc. Natl. Acad. Sci. USA  92, 9333-9337

1994                      Koelle D.M., Corey L., Burke R.L., Eisenberg R.J., Cohen G.H., Pichyangkura R., and Triezenberg S.J. (1994). Antigen specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions. J. Virol. 68, 2803-2810

Local Journal Articles

2011                      ธเนศ จิระพรประเสริฐ; กนกวรรณ เสรีภาพ; ปรีดา บุญ-หลง; รัฐ พิชญางกูร; ศุภจิตรา ชัชวาลย์ (2554) ผลของชนิดและความเข้มข้นของไคโตซานที่มีต่อการเติบโตของผักสลัด ฟิลเลย์ ไอซ์เบิร์ก                               ที่ปลูกด้วยวิธีไฮโดรพอนิก วารสารวิทยาศาสตร์เกษตร  42(2 (Suppl.)) : 29-32

2006                     สมชาย ชคตระการ, กันยา เย็นใจ, รัฐ พิชญางกูร (2549) ผลของโอลิโกไคโตซานต่อการเจริญเติบโต และ ผลผลิตของผักกาดหอมในระบบการปลูกพืชโดยไม่ใช้ดิน ; วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยธรรมศาสตร์ ปีที่ 14 ฉบับที่ 1 : 16-24

1999                     รัฐ พิชญางกูร (2542) การส่งถ่ายดีเอ็นเอเข้าสู่เซลล์ของ Plasmodium sp. และผลกระทบต่อ การศึกษาชีววิทยาโมเลกุลของเชื้อมาลาเรีย  วารสารวิจัยวิทยาศาสตร์การแพทย์    ปีที่ 13 ฉบับที่ 1 : 31-37 Pichyangkura R. (1999) Transfection in Plasmodium sp. and the impact on molecular biology of the malaria parasite. Thai Journal of Health Science, 13 (1), 31-37